Important functional pathways are dysregulated in MDS cases with high expression of cxcr2. (A) Gene expression profiles from samples with low and high CXCR2 were compared, and differentially expressed transcripts were identified (FDR < 0.1). (B) Significantly dysregulated pathways are shown. The gene signature of high CXCR2 MDS cases is similar to previously published preleukemic stem cell signatures. (C) Gene Set Enrichment Analysis plots show significant enrichment of 2 recent preleukemic gene expression signatures.