The figure illustrates platelets activated by ADP that aggregate. After treatment with the ADP antagonist ticagrelor, aggregation is limited. If bleeding occurs or the patient needs to undergo urgent surgery, elimination of ticagrelor is currently dependent on liver elimination requiring 3 to 5 days. With the high-affinity Fab ticagrelor antidote, the elimination can be achieved within 30 minutes. After elimination of ticagrelor, the platelets can aggregate in response to ADP again and bleeding can be mitigated. Original magnification ×10 400. Professional illustration by Patrick Lane, ScEYEnce Studios.