Figure 2
![Figure 2. MCL-1 is essential for recovery of the hematopoietic system from sublethal γ-irradiation. (A) Mice (wild-type or Mcl-1+/−) were subjected to 8 Gy γ-irradiation and their survival monitored (median survival of Mcl-1+/− mice: 11 days; log-rank [Mantle-Cox] test, P < .0001); n = 14 (wild-type), 10 (Mcl-1+/−) mice. Pooled results from 2 independent experiments are shown. (B) Histologic analysis of the bone marrow of wild-type and Mcl-1+/− mice was performed 12 days after γ-irradiation. Representative hematoxylin and eosin (H&E)-stained bone marrow sections (×20 objective, 500 µm scale bar).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/125/21/10.1182_blood-2015-01-621250/4/3273f2.jpeg?Expires=1724229756&Signature=MsxPFulIPbxa9xcwbpf6MtQafTtrPiVisqMT-8l0CBe6fGMpSTtIkRCQE6m7mgbpT5aH6bao-3UEZzRMdnELaFWytGJF4aw9St3CyqK4fXkRcKujL1RPLGrBtlLHTBHuuhHAHqxbT5WO5LeF0-VsMYr4W9C3U2V9cTeFJrpKVhIOlKIQVKDkM6NSuF47otOWQtmfCN80o3AQf6MhX-iS8yktx~KAOzv6h3DRsxvZZsX1OQPngEjkNbJjBqYqhUphbrTIcGsofdCFtkmk7UuTpXABIfJwHjgVAZMWZr-5MVRITxwyyJ6EV6GLiOKBR3jiFP8JCNq6OvHDuZ~rgqBklQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
MCL-1 is essential for recovery of the hematopoietic system from sublethal γ-irradiation. (A) Mice (wild-type or Mcl-1+/−) were subjected to 8 Gy γ-irradiation and their survival monitored (median survival of Mcl-1+/− mice: 11 days; log-rank [Mantle-Cox] test, P < .0001); n = 14 (wild-type), 10 (Mcl-1+/−) mice. Pooled results from 2 independent experiments are shown. (B) Histologic analysis of the bone marrow of wild-type and Mcl-1+/− mice was performed 12 days after γ-irradiation. Representative hematoxylin and eosin (H&E)-stained bone marrow sections (×20 objective, 500 µm scale bar).
