PCA-based classification model for the differential diagnosis between the Waldenström clone (pooled data from IgM MGUS, smoldering, and symptomatic WM patients) vs clonal B cells from patients with MZL and B-CLL. The mean intensity fluorescence of the top 3 markers to discriminate between iPEPs from Waldenström vs clonal B cells from (A) MZL and (B) CLL patients are illustrated by the respective box plots. The pink arrows in A denote MZL patients inside standard deviation curves of the Waldenström clone iPEP.