iPEP of clonal B cells from IgM MGUS, smoldering WM, and symptomatic WM according to disease stage and MYD88 mutational status. (A) iPEP of clonal B cells from IgM MGUS (n = 15; green), smoldering WM (n = 19; blue), and symptomatic WM (n = 11; red) patients. In the PCA graphic view, every patient is represented by a single dot and disease reference groups by 1 (dash lines) and 2 (solid lines) standard deviation curves. (B) PCA of iPEP of clonal B cells from patients with MYD88 mutated (n = 22; dark green dots and lines) vs wild-type MYD88 (n = 3; brown dots and lines).