Figure 4
Figure 4. 211At radiosensitivity of NOD/SCID mice. Non-tumor–bearing NOD/SCID mice (n = 5/group) received 230 µg of 1F5-B10 labeled with either 10 or 20 µCi of 211At followed by bone marrow rescue (1 × 107 bone marrow cells IV from syngeneic donors) 2 days after treatment. The Kaplan-Meier survival curves demonstrates that 20-µCi [211At]1F5-B10 was universally lethal within in 5 days, whereas the 10-µCi dose was well tolerated.

211At radiosensitivity of NOD/SCID mice. Non-tumor–bearing NOD/SCID mice (n = 5/group) received 230 µg of 1F5-B10 labeled with either 10 or 20 µCi of 211At followed by bone marrow rescue (1 × 107 bone marrow cells IV from syngeneic donors) 2 days after treatment. The Kaplan-Meier survival curves demonstrates that 20-µCi [211At]1F5-B10 was universally lethal within in 5 days, whereas the 10-µCi dose was well tolerated.

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