P15 and MyoD promoter methylation.P15 (A) and MyoD (B) promoter methylation were determined in 10 patients with low and 10 with high 5hmC levels. For each CpG, the methylation status is indicated with shaded boxes. Patients with low 5hmC show more P15 promoter methylation than patients with high 5hmC levels, whereas there is no difference in MyoD promoter methylation. UPN, unique patient number.