Molecular markers in different groups of 5hmC levels. Patients are ranked from low to high 5hmC levels, and the different 5hmC groups used for the OS analysis are indicated. Per patient, all mutations are indicated with small colored boxes. Light gray boxes represent no mutation and dark gray boxes not determined/unknown. TET2 and IDH mutations are present in patients with low 5hmC, whereas AML1-ETO and MLL translocations are more frequently found in patients with high 5hmC levels. ITD, internal tandem duplication; transl, translocation.