Binding of antiplatelet antibodies (Ab) to platelets (Plt) triggers platelet oxidation, which also requires the phagocyte NADPH oxidase system. Platelet oxidation exposes oxidized phosphorylcholine (Ox PC) residues from the platelet membrane, providing a Ca²⁺-dependent binding platform for CRP. CRP subsequently boosts antibody-mediated platelet phagocytosis via phagocytic FcRs. The figure is based on Figure 7 in the article by Kapur et al that begins on page 1793.