Activities of respiratory chain complexes do not increase in primary AML samples in parallel with mitochondrial mass. The activities of respiratory complexes I-V were measured in isolated mitochondria from primary normal hematopoietic (G-CSF mobilized peripheral blood mononuclear cells) and primary AML samples. (A) Complex activity was normalized to total protein concentration. (B) Complex activity was normalized to mitochondrial mass using citrate synthase activity. *P < .05; **P < .001; ***P < .0001 as determined by unpaired Student t test.