Illustration of the proposed role for CRP in IgG-mediated platelet destruction. Antiplatelet IgG antibodies from serum bind to platelets (1). Platelet oxidation (OX) results in phosphorylcholine exposure, independently of platelet FcγRIIa, but requires the phagocyte NADPH oxidation system (2). Subsequently, CRP present in the serum binds to platelet phosphorylcholine in a Ca²⁺-dependent manner (3). This potentiates the uptake and degradation of the platelets via Fc receptors of the phagocyte (4).