In vivo thrombosis. Representative images of n = 3 (for each mouse) of in vivo thrombosis experiments. FeCl₃ injury of mesenteric vessels was performed in VavCre/JAK2^V617F mice (A) or SCLCreER^t/ JAK2^V617F mice 2 months after treatment by tamoxifen (B and C). The accumulation of rhodamin 6G-stained platelets (in red) was recorded. The white arrow in panel B indicates signs of accelerated thrombus lysis, and the white circles in panel C indicate thrombus embolization. Note that the time to occlusion in JAK2^V617F KI mice is reduced as compared with their controls. Original magnification ×5 for all panels.