VWF structure. (A) Graphic representation of the VWF monomer with its different domains and their binding ligands. Note that the D1 and D2 domains (propeptide) are cleaved upon released of VWF from the endothelial cell. (B) Depiction of the ability of VWF monomers to dimerize through the C terminus and of those dimers to multimerize via disulfide bonds at the D3 domain, reaching sizes >20 000 kDa.