TTNT for key therapies according to T (skin) score. (A) TTNT for PUVA, α-interferon, HDACi, TSEB, and chemotherapy in patients with T2 disease. (B) TTNT for α-interferon, HDACi, chemotherapy, TSEB, and low-dose methotrexate in patients with T3 disease. (C) TTNT for α-interferon, HDACi, chemotherapy, ECP, and TSEB in patients with patients with T4 disease.