TTNT for α-interferon, HDACi, and chemotherapy across treatment lines. (A) TTNT at first line for the 3 therapies is shown. There is no significant difference in efficacy. (B) TTNT at mid line (2nd-4th line) shows α-interferon is the best performer. (C) TTNT at late line (5th line and later) shows a trend toward α-interferon.