Figure 7
Figure 7. Proposed model depicting PAK-mediated Akt translocation to the membrane downstream of the Gq pathway in platelets. Activation of the Gq pathway results in translocation of the PAK-Akt complex to the membrane via interaction of PAK with membrane-localized Rac1 in a novel PIP3-independent mechanism. Akt, after translocation, is phosphorylated by PDK1 and mTORC2 by the Gi pathway through secreted ADP.

Proposed model depicting PAK-mediated Akt translocation to the membrane downstream of the Gq pathway in platelets. Activation of the Gq pathway results in translocation of the PAK-Akt complex to the membrane via interaction of PAK with membrane-localized Rac1 in a novel PIP3-independent mechanism. Akt, after translocation, is phosphorylated by PDK1 and mTORC2 by the Gi pathway through secreted ADP.

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