Loss of one allele of Trp53 or Ink4a-Arf does not rescue defects in B-cell development imposed by Moz haploinsufficiency. (A) Kaplan-Meier curves depicting lymphoma-free survival of Moz^+/−; Eμ-Myc^T/+; Trp53^+/− and Moz^+/+; Eμ-Myc^T/+; Trp53^+/− mice, as well as Moz^+/−; Eμ-Myc^T/+; Ink4a-Arf^+/− and Moz^+/+; Eμ-Myc^T/+; Ink4a-Arf^+/− mice. (B) Quantification of pre–B-cell progenitors in the BM, spleen, and peripheral blood of Moz^+/−; Eμ-Myc^T/+; Trp53^+/− and Moz^+/+; Eμ-Myc^T/+; Trp53^+/− mice. (C) Enumeration of pre–B-cells in the BM, spleen, and peripheral blood of Moz^+/−; Eμ-Myc^T/+; Ink4a-Arf^+/− and Moz^+/+; Eμ-Myc^T/+; Ink4a-Arf^+/− mice. Data are presented as mean ± SEM. Asterisks indicate a statistically significant difference between genotypes as indicated at *P < .05, **P < .01, and ***P < .001. Cell surface markers used to discriminate between cell populations are provided in supplemental Table 8.