Inhibition of apoptosis increases the frequency of ASCs in preneoplastic v-abl mice. The total number of ASCs in the (A) spleen and (B) bone marrow (per femur) of healthy young mice (7-8 weeks) was determined by ELISPOT assay; total tissue cellularity is shown in supplemental Figure 2. bim^−/−v-abl and littermates (white fill), n = 3 to 6; mcl-1/v-abl and littermates (gray fill), n = 10 to 12; bcl-2/v-abl and littermates (black fill), n = 8. Mean ± SEM. *P < .05, **P < .01, ***P < .001, Student t test. Statistical analysis for WT vs bim^−/−v-abl and v-abl vs bim^−/− are not shown.