T_H17 cells redirected with ICOS endodomain show increased expression of CD161. Redirected T_H17 cells were cocultured with irradiated APC expressing mesothelin. (A) CD161 expression by CAR⁺CD4⁺ T cells in response to mesothelin-specific stimulation was analyzed by flow cytometry at indicated time points. The percentage of CAR⁺ T_H17 (B-C) or T_H0 (D) cells expressing CD161 at day 8 after stimulation in several different normal donors is plotted. **P < .01 and ***P < .001.