Platelets from dKO mice are dysfunctional. (A) Micrographs of collagen-coated slides after perfusion of WT^lox and dKO reconstituted blood containing the same number of platelets (left). The average coverage measured as green fluorescence over the total surface was quantitated with ImageJ software. (B) Tail bleeding time of WT^lox and dKO mice is depicted. (C) FCA shows the aggregation capacity of platelets when stimulated with different agonists. *P < .05; **P < .01; ***P < .001.