Erythroid cells from mtDNA-mutator mice show increased expression of genes involved in OXPHOS and ribosomal subunits. (A-C) RNA was extracted from Ter119⁺ erythroid cells positively selected from the bone marrow of phlebotomized mice by using magnetic beads and used for expression profile analyses. Results of gene set–enrichment analysis are shown in supplemental Table 5. Enrichment plots and heat maps for the top 20 genes contributing to the enrichment scores for 3 selected gene sets are shown in panels A and B, respectively. A diagram of established interactions (physical, biochemical, and regulatory) among these 60 genes was generated by using ConsensusPathDB (induced network model) maintained by the Max Plank Institute and is shown in panel C.