ASXL2 mutations are frequent in AML patients bearing the t(8;21) translocation and are associated with a trend for increased risk for relapse. (A) Gene diagram depicting ASXL2 mutations in adult and pediatric patients with t(8;21) AML. (B) Pattern of molecular and cytogenetic lesions in patients with t(8;21) AML. Each column represents 1 of the 110 t(8;21) AML samples sequenced here. Patient demographics (adult vs pediatric sample) are also included. Cumulative incidence of relapse according to enrollment ASXL2 and ASXL1 mutation status in (C) the entire t(8;21) AML cohort and (D) adult patients who achieved more than 3 log-fold reduction in RUNX1-RUNX1T1 transcripts before initiation of second consolidation course.