The Wnt pathway is significantly mutated in CLL (P = .00067). (A) Cellular localization of mutations in Wnt pathway components in CLL (light red). *Pathway genes mutated in more than 1 CLL sample. (B) Clinical characteristics of CLL samples harboring Wnt pathway mutations, as well as the putative function of the mutated Wnt pathway genes and their genomic localization. A, pathway activator; R, pathway repressor.