Mosaic domain structure of VWF. (A) Cysteines are vertical lines and are connected for disulfide bonds assigned chemically,^105,106  by structure,^7,48  or by homology.²  N- and O-linked glycans are closed and open lollipops, respectively.¹⁰  Domains are scaled to length and residues are shown with pre-pro numbering. (B-F) D assembly modules. (G-I) A, C, and CTCK domains. Disulfides assigned as described above are connected with colored lines. Secondary structures are overlined and disordered residues are in italics in structurally characterized TIL′,⁷  E′,⁷  A1,^{64-66,107,108}  A2,^51,54,55  A3,^77,107,109  and CTCK domains.⁴⁸  N and O-glycosylated residues and the RGD motif are in red. (J) D′ ribbon diagram with disulfides shown with yellow sulfur atoms.⁷