ASXL gene mutations in t(8;21) AML. (A) ASXL2 is the second-most commonly mutated gene in AML with t(8;21). The heatmap visualizes the spectrum of recurrent gene mutations in 110 adult and pediatric patients with AML and t(8;21). ASXL2 and ASXL1 mutations were mutually exclusive. The figure has been adapted from Figure 1 in the article by Micol et al that begins on page 1445. (B) ASXL2 gene mutations do not affect overall survival in t(8;21) AML. The Kaplan-Meier curves depict overall survival of patients with mutated ASXL1, mutated ASXL2, or wild-type ASXL1/ASXL2. No difference between the 3 groups was observed. The figure has been adapted from supplemental Figure 4 in the article by Micol et al that begins on page 1445.