Figure 3
![Figure 3. Association of HLA-DRB1 and HLA-DQB1 alleles with asparaginase hypersensitivity. Using a general linear model adjusted for gender, age, treatment arm, and ALL immunophenotype, (A) HLA-DRB1*07:01 (P = .001 [Padjusted = .023]) was associated with asparaginase hypersensitivities within the discovery cohort (n = 541). The dashed horizontal red line identifies a permuted significance threshold of P < .05 that is adjusted for multiple testing. Patients with the HLA-DRB1*07:01 allele had a higher incidence of hypersensitivity compared with patients that did not have the allele within the (B) discovery cohort (n = 541), (C) validation cohort (n = 1329), and (D) the combined cohort (n = 1870).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/8/10.1182_blood-2014-03-563742/4/1266f3.jpeg?Expires=1722404956&Signature=rRQYvtxLMheBWaQ7-DocS04UT2Gk0OBA8UEZJl~E7PAxCD67yquDRfxfcm1afsToNmsCP6B5trt59UmK7foaHxEYKrOyvZ-7wpXxheqIstX7CPCRwAddFj6z03BX~GqIdML0GM3qe3Mspn92D~g-dB2J0NfK6fGkMa0jxM18-GZdVksMzTdb0Or3kqmXhppuRXK9Y2wqNVhs2NrNhCDY22xxy~yj9tWTygv-EnYvY6imIg9lxS0eQbV9bMtFWia3gO7BKOVpsTJpjkcHpQ0AqGAEjSVFxCarqNO2mpDDJWNLHiOA~~toJPs90W8i-naRy12szhX11oKbqHBSNHJqpg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Association of HLA-DRB1 and HLA-DQB1 alleles with asparaginase hypersensitivity. Using a general linear model adjusted for gender, age, treatment arm, and ALL immunophenotype, (A) HLA-DRB1*07:01 (P = .001 [Padjusted = .023]) was associated with asparaginase hypersensitivities within the discovery cohort (n = 541). The dashed horizontal red line identifies a permuted significance threshold of P < .05 that is adjusted for multiple testing. Patients with the HLA-DRB1*07:01 allele had a higher incidence of hypersensitivity compared with patients that did not have the allele within the (B) discovery cohort (n = 541), (C) validation cohort (n = 1329), and (D) the combined cohort (n = 1870).
