Box-and-whisker plot of the number of variants per exome trio for de novo and autosomal-dominant inheritance models. The number of variants for the BMT trio significantly deviates from the normal range of non-BMT trios. The non-BMT control trios were randomly chosen from a group of 25 trios and include 15 individuals in 5 unrelated non-BMT trios. The bars represent the greatest and least values excluding the outliers. The values at the top and bottom of the boxes represent the upper and lower quartiles, whereas the line indicates the median.