![Figure 1. Morphologic and cytogenetic analysis of BM sample of the APL case with t(3;17)(q26;q21),t(7;17)(q11.2;q21) translocation. (A) The May-Giemsa staining. BM cells were shown to be blocked at the hypergranular promyelocytic stage lacking Auer rods. (B) Myeloperoxidase staining. (C) Specific esterase staining. (D) Nonspecific esterase staining. (B-D) Cellular histochemical staining examination exhibited high positive rates of blast cells. (E) FISH analysis. PML probe (orange signal) and RARα probe (green signal) were used. No PML-RARα was detected. (F) Karyotype analysis. 46,XY,t(3;17)(q26;q21),t(7;17)(q11.2;q21) was found in 14 metaphases among 15 metaphases detected. (G) Karyotype analysis of relapsed BM cells. A more complex recurring chromosomal transcription, 46,XY,t(3;17)(q26;q21),add(5)(q32),del(6)(q22q24),t(7;17)(q11.2;q21),add(10)(q26),del(11)(p14)[13]/46,XY[1], was observed in 13 metaphases among 14 metaphases detected. The rearrangements and break points in panels F and G were indicated by arrows.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/6/10.1182_blood-2013-10-528596/4/936f1.jpeg?Expires=1724233151&Signature=byR0QbXSv3CPKV5Zkzc32aI6~jfI8mBZWNyI30GlFMyoFc9eDCyNoaJuoJ~BF4Rzpn75YqFC7cXTG~mi7UXNb8obZpsrSNkOCds8LVgZhvDl21CBy5tDbB9vXIw4ODb~DpDv1-hKZqf6onTArgSjy3oIjCQe-z2BQhryTt7blzdlR27nmNtQ2Zo0jJYg~Cc57-yCwBvoxzulrU~RH89izOiDUIW7PEICCJtDus0u-XCM1s4zii-JUYO2vdIHFKg5wCuFEJn1qoynkiCfQSWL-jGSnHCbame3wulrFmfDxfrwNc17BvK4IlKbhUKP96iCyLMNKgEb71Y3iqro~EKRgw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Morphologic and cytogenetic analysis of BM sample of the APL case with t(3;17)(q26;q21),t(7;17)(q11.2;q21) translocation. (A) The May-Giemsa staining. BM cells were shown to be blocked at the hypergranular promyelocytic stage lacking Auer rods. (B) Myeloperoxidase staining. (C) Specific esterase staining. (D) Nonspecific esterase staining. (B-D) Cellular histochemical staining examination exhibited high positive rates of blast cells. (E) FISH analysis. PML probe (orange signal) and RARα probe (green signal) were used. No PML-RARα was detected. (F) Karyotype analysis. 46,XY,t(3;17)(q26;q21),t(7;17)(q11.2;q21) was found in 14 metaphases among 15 metaphases detected. (G) Karyotype analysis of relapsed BM cells. A more complex recurring chromosomal transcription, 46,XY,t(3;17)(q26;q21),add(5)(q32),del(6)(q22q24),t(7;17)(q11.2;q21),add(10)(q26),del(11)(p14)[13]/46,XY[1], was observed in 13 metaphases among 14 metaphases detected. The rearrangements and break points in panels F and G were indicated by arrows.
