T-ALL patients lacking PTEN/AKT mutations and NOTCH-activating mutations have a good outcome. RFS curves for T-ALL patients treated on (A) Dutch DCOG ALL7/8 or 9 protocols or (B) German COALL-97/03 protocols. Green line: NOTCH-activating mutations including mutations in NOTCH and FBXW7; red line: PTEN-inactivating or AKT-activating mutations; blue line: NOTCH-activating mutations and PTEN-inactivating or AKT-activating mutations combined; black line: wild type for NOTCH/FBXW7 and PTEN/AKT. Tick marks in figures refer to patients that are lost from further follow-up. The numbers of patients included at various time points in these studies are shown.