Fanca^−/− MKs present defects in ploidy and endoreduplication. Graphic representation of MKs ploidy and calculated mean of ploidy (A) at baseline (n = 5) and (B) after 3 days of differentiation in vitro (n = 6, *P < .05, Student t test). (C) Representative plots of CD41-positive cells and BrdU analysis of endomitotic cycles (left); percentages of WT and Fanca^−/− MKs at different phases of endomitosis (right; G1 in black; S in gray; G2/G1 in red; n = 3 per group). The results are presented as means ± SEM. *P < .05, 2-way analysis of variance test.