Association between markers at the time of TMA diagnosis and death by 1 year after HSCT. At the time of TMA diagnosis, a hemoglobin ≤8 g/dL, proteinuria (defined either as ≥30 mg/dL of protein on a random urinalysis or a random urine protein/creatinine [Ur prot/creat] ratio >2 mg/mg), and a soluble membrane attack complex (sC5b-9) concentration above the upper limit of normal were all significantly associated with an increased risk of death. Haptoglobin was higher in patients who died, likely representing an acute inflammatory state.