Change in APTT after weekly IV injection of the mouse anti-primate FVIII neutralizing antibody VIII-2236 in cynomolgus monkeys. VIII-2236 was injected at 3 or 10 mg/kg IV doses to cynomolgus monkeys on days 0, 7, 14, and 21. Citrated blood was collected on days 0, 3, 7, 10, 14, 17, 21, 24, and 28 (before and 2 hours after VIII-2236 injection on days 0, 7, 14, and 21). The time course of APTT is shown for each monkey.