Chemotherapy restores the T-cell compartment in leukemic mice. Mice were challenged with C1498 cells, and 24 hours later three 3-mg doses of cytarabine were administered intraperitoneally 10 hours apart. (A-D) The T-cell populations in the spleen were analyzed and identified as CD3⁺ expressing either CD8 or CD4. The proportion of live cells expressing (A) CD3 and CD8 or (B) CD3 and CD4. The MFI of CD44 (C) CD8⁺ cells and (D) CD4⁺ cells. (A-D) Represent 3 experiments, with 5 mice per group. *P < .05; **P < .01; ***P < .001 (1-way ANOVA with a Bonferroni posttest).