American Society of Hematology

Figure 2

$Figure 2. Altered hematopoiesis in Cdk4 R24C and Cdk6 R31C mice. (A) Analysis of B-, T-, and myeloid cells in the spleen (n = 5 per genotype). (B) Analysis of B-cell development in the bone marrow determining Hardy fractions. (C) Analysis of the LSK fraction in the bone marrow. (D) Analysis of HSCs and multipotent progenitor cells (MPPs). For all experiments described in panels c-d, 5 Cdk4R/R single-mutant mice, 7 Cdk6R/R single mutants and wild-type mice, and 5 double-mutant mice were analyzed and compared. All data are given as the percentage of living cells. Significant differences are indicated as follows: *P < .05; **P < .01; ***P < .001. One-way ANOVA including Bonferroni’s multiple comparison test.$

Altered hematopoiesis in Cdk4 R24C and Cdk6 R31C mice. (A) Analysis of B-, T-, and myeloid cells in the spleen (n = 5 per genotype). (B) Analysis of B-cell development in the bone marrow determining Hardy fractions. (C) Analysis of the LSK fraction in the bone marrow. (D) Analysis of HSCs and multipotent progenitor cells (MPPs). For all experiments described in panels c-d, 5 Cdk4^R/R single-mutant mice, 7 Cdk6^R/R single mutants and wild-type mice, and 5 double-mutant mice were analyzed and compared. All data are given as the percentage of living cells. Significant differences are indicated as follows: *P < .05; **P < .01; ***P < .001. One-way ANOVA including Bonferroni’s multiple comparison test.

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