GEP of bone marrow biopsy material. GEP of whole bone marrow biopsy material encompasses in both hematopoietic and bone marrow microenvironmental tissues. In the case of myeloma and precursor conditions, myeloma plasma cells coexist in the biopsy material with normal hematopoietic and stromal elements. Marked differences in the 37-gene score were noted between CMM, AMM, MGUS, CR, and normal donors (A). Myeloma patients qualifying for CR status and whose bone marrow biopsy becomes normal donor-like (“normalization”) enjoy superior CR duration than their counterparts not qualifying for normalization. CRD according to “normalization” of bone marrow biopsies of patients with MM was compared (CRD by normalization status for patients in CR using first GEP sample after 2 years of CR) (B).