Response and progression estimates by protocol. The cumulative incidence of CR (A) translates into longer CR duration (CRD) (B). Of note, despite similar times of onset of CR in TT2+Thal and TT3a, CRD is far superior with TT3a, suggesting that a deeper level of CR was effectuated. With transition to later protocols, the slopes of time to progression (TTP) (C) and time to relapse (TTR) from CR (D) progressively flatten and reach lower plateaus. (A) Cumulative incidence of CR. (B) CRD by protocol. (C) TTP. (D) TTR from CR.