Survival estimates by protocol. Overall survival (OS) and PFS curves (A-D) show progressive narrowing with transition from TT1 to TT2-Thal to TT2+Thal to TT3a. Progressive improvement between protocols in OS and PFS is apparent (E-F). (A) OS and PFS: TT1. (B) OS and PFS: TT2 - Thal. (C) OS and PFS: TT2 + Thal. (D) OS and PFS: TT3a. (E) OS by protocol. (F) PFS by protocol.