Effects of treatment with AZD1480 on MF NRCs. (A-B) The degree of SP MF hematopoietic cell engraftment is indicated by the percentage of hCD45⁺ cells detected within the marrow (A) and spleen (B) of the NSG mice. P all >.05 for each patient studied (n = 6). Horizontal bars indicate the mean of percentage of hCD45⁺ cells in the BM and spleen of NSG mice. (C) Relative hCD45⁺ cell chimerism achieved in the BM and spleens of mice receiving SP MF CD34⁺ cells treated with cytokine plus AZD1480 to that achieved in mice receiving cells treated with cytokines alone. BM and spleen: P > .05 (n = 6).