OS of patients with TP53 mutation and/or deletion. OS was analyzed in patients with (TP53mut; n = 67) and without (TP53wt; n = 322) TP53 mutation (A); in patients with (TP53del; n = 34) and without (n = 217) TP53 deletion (B); and in patients with TP53 mutation without TP53 deletion (TP53mut sole; n = 22), patients with TP53 deletion without TP53 mutation (TP53del sole; n = 16), in patients that showed alterations in both alleles (TP53 2hits, n = 29) and in patients without aberrations in TP53 (TP53wt; n = 188) (C).