Progression to dialysis in the overall population according to the novel response and progression criteria (3-month landmark analysis). (A) Renal progression (P = .002). (B) Renal response (P < .001). (C) Hematologic response (P = .013). Renal progression is defined as a decrease in eGFR ≥25%. Renal response is defined as a decrease in proteinuria ≥30% or a drop of proteinuria below 0.5 g/24 h in the absence of renal progression. VGPR is defined as dFLC <40 mg/L.