Progression to dialysis in the testing and validation cohorts according to the novel response and progression criteria (6-month landmark analysis). (A) Renal progression in the testing cohort (P < .001). (B) Renal progression in the validation cohort (P < .001). (C) Renal response in the testing cohort (P < .001). (D) Renal response in the validation cohort (P = .039). (E) Hematologic response in the testing cohort (P = .014). (F) Hematologic response in the validation cohort (P < .001). Renal progression is defined as a decrease in eGFR ≥25%. Renal response is defined as a decrease in proteinuria ≥30% or a drop of proteinuria below 0.5 g/24 h in the absence of renal progression. VGPR is defined as dFLC <40 mg/L.