Smac mimetic and dexamethasone cooperate to induce cell death in ALL cell lines. (A-B) Cells were treated for 72 hours with indicated concentrations of dexamethasone (A) or prednisolone (B) and/or BV6. Cell death was determined by forward/side scatter analysis and flow cytometry. (C) Clonogenic survival was assessed by colony assay after treatment with dexamethasone (Jurkat: 300 µM, Molt-4: 200 µM) and/or BV6 (Jurkat: 7 µM, Molt-4: 5 µM). The percentage of colonies relative to solvent control is shown. Mean and standard deviation (SD) of 3 experiments performed in triplicate are shown; *P < .05; **P < .01.