Median number of somatic mutations identified by whole-exome sequencing. Comparison of mutation load between primary and relapse DLBCL samples (A), or between tumors with and without mutations in MMR genes (B-C). MMR-mutated tumors presented a significantly higher median of mutations (**P < .01, Mann-Whitney U test) than nonmutated cases. (B) All mutations. (C) InDels.