Figure 2
![Figure 2. Hepatic hepcidin gene expression is preserved in mice with global deficiency of ActR2a but is markedly reduced in mice lacking both ActR2a and BMPR2. Hepatic levels of mRNAs encoding ActR2a (A), BMPR2 (B), hepcidin (C), and Id1 (D) were measured in 10- to 12-week-old female mice, globally deficient for ActR2a, without or with hepatocyte-specific deficiency of BMPR2 (ActR2a−/−;Bmpr2fl/fl [n = 23] and ActR2a−/−;Bmpr2fl/fl;Alb-Cre [n = 13], respectively), as well as control mice (ActR2a+/+;Bmpr2fl/fl [n = 7]). Mice carrying the Cre recombinase transgene are indicated by “Cre +”. ANOVAs P < .009; *P < .0001 vs ActR2a+/+;Bmpr2fl/fl mice; #P < .003 vs ActR2a−/−;Bmpr2fl/fl mice; §P < .05 vs ActR2a+/+;Bmpr2fl/fl mice.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/13/10.1182_blood-2014-04-572644/4/2116f2.jpeg?Expires=1724224234&Signature=aQb~mf-IAiOQ-I6fFlDXgKHYZOestiGSQG0m-8VecVT-VxRldGBnxKbZJG7jRgj6f2o-fXc-dAKVhskuYwS0TZ2F7k65ciG~G0uo7KFAr1dvKAJ00yQXQTfXpW1-cpkgwiqqI0FSlfUXLzEHyaLD8cKOLFw7icaBKUv5W~d3feBcMdImKdxJUl-jEpOmlj0D-oHPgzboBwalVgH06J0aoGI1QDsOGrWg16i9USA35uyKVaephTUfE-6tNUIhF1kSXS3UZ~uiShzXUrlQ5AJneS2Gp2mTxlIzrbHvTyz9g7uH-o3fr3yCnMU1FuUAQb9X86m9ntJ~HwE0NaiJNGLx8w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Hepatic hepcidin gene expression is preserved in mice with global deficiency of ActR2a but is markedly reduced in mice lacking both ActR2a and BMPR2. Hepatic levels of mRNAs encoding ActR2a (A), BMPR2 (B), hepcidin (C), and Id1 (D) were measured in 10- to 12-week-old female mice, globally deficient for ActR2a, without or with hepatocyte-specific deficiency of BMPR2 (ActR2a−/−;Bmpr2fl/fl [n = 23] and ActR2a−/−;Bmpr2fl/fl;Alb-Cre [n = 13], respectively), as well as control mice (ActR2a+/+;Bmpr2fl/fl [n = 7]). Mice carrying the Cre recombinase transgene are indicated by “Cre +”. ANOVAs P < .009; *P < .0001 vs ActR2a+/+;Bmpr2fl/fl mice; #P < .003 vs ActR2a−/−;Bmpr2fl/fl mice; §P < .05 vs ActR2a+/+;Bmpr2fl/fl mice.
