Figure 1
Figure 1. Hepatocyte-specific deficiency of BMPR2 does not induce iron overload. Hepatic levels of mRNAs encoding BMPR2 (A) and hepcidin (B), as well as serum iron levels (C) and liver iron content (D), were measured in 10-week-old female mice with hepatocyte-specific deficiency of BMPR2 (Bmpr2fl/fl;Alb-Cre, n = 7) and age-matched control mice (Bmpr2fl/fl, n = 12). Mice carrying the Cre recombinase transgene are indicated by “Cre +”. Student t test, *P < .009 vs Bmpr2fl/fl mice.

Hepatocyte-specific deficiency of BMPR2 does not induce iron overload. Hepatic levels of mRNAs encoding BMPR2 (A) and hepcidin (B), as well as serum iron levels (C) and liver iron content (D), were measured in 10-week-old female mice with hepatocyte-specific deficiency of BMPR2 (Bmpr2fl/fl;Alb-Cre, n = 7) and age-matched control mice (Bmpr2fl/fl, n = 12). Mice carrying the Cre recombinase transgene are indicated by “Cre +”. Student t test, *P < .009 vs Bmpr2fl/fl mice.

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