COX-1 deficiency impairs B-cell homeostasis. (A) Representative flow cytometry profiles of BM, spleen (SP), peripheral blood (PB), and lymph node (LN) tissues from homozygous COX-1^−/− mice and WT littermates to identify total B (B220⁺CD19⁺) and T (CD3e⁺) lymphocytes. Numbers in the plots indicate percentages in each gate. (B) Percentages and (C) absolute cell counts of B cells, T cells, and T-cell subsets in the indicated tissues of WT and COX-1^−/− mice. (A-C) Each group included 6 mice, and measurements were repeated 3 times for each mouse; data are shown as mean ± standard error of the mean (SEM). *P < .05, **P < .01 compared with controls using unpaired Student t tests.