Duration of study treatment of 34 patients with MM. Arrows indicate patients who were still ongoing at the time of study closure. Those patients are continuing treatment with afuresertib on a continuation protocol. Two patients were enrolled in dose escalation (part 1) and were administered 100 mg per day (indicated by *); the remaining patients were administered 125 mg per day. NE, not evaluable; PD, progressive disease; SD, stable disease.