Various ligands of EPCR. In addition to (A) acting as a cellular receptor for protein C (PC) and APC, (B) EPCR was shown to interact with factor VII (FVII) and factor VIIa (FVIIa), (C) Mac1 on leukocytes, either directly or indirectly through its binding to proteinase 3 (PR3), (D) P falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by P falciparum-infected erythrocyte, and (E) a variant of γδ T-cell receptor induced in response to stress elicited by infection or malignancy. PC/APC, FVII/FVIIa, Mac1, and PfEMP1 bind EPCR at the same or an overlapping site.