Intracranial, major gastrointestinal, fatal, and clinically relevant nonmajor bleeding. Intracranial bleeding numbers comprise fatal and nonfatal events. Because CRNM bleeding was not a predefined outcome on its own in both RE-COVER studies, we obtained these numbers by subtracting major bleeding numbers from the composite of major and CRNM bleeding. Heterogeneity: intracranial bleeding I² = 0%, P = .66; major GI bleeding I² = 51%, P = .07; fatal bleeding I² = 0%, P = .86; CRNM bleeding I² = 85%, P < .00001. GI, gastrointestinal.