Platelet responses obtained with Optimul in patients with known mutations. (A) Patient with a mutation in the TP receptor. (B) Patient with a mutation in the P2Y₁₂ receptor. Dose-response curves presented as median and interquartile range. Open squares represent healthy volunteers, and the black triangles represent the participant with a thromboxane receptor mutation in A and a P2Y₁₂ receptor mutation in B.